Figure 4d. Microglia-specific eQTL colocalization in FCGR2A.#
The CoS-gene link from microglia-specific eQTL colocalization in FCGR2A is validated by CRISPRi in K562 cells.
res <- readRDS("Figure_4d_FCGR2A.rds")
options(repr.plot.width = 8, repr.plot.height = 8)
colocboost_plot(res, variant_coord = TRUE, plot_cols = 1)
res$cos_details$cos_outcomes_npc
$`cos1:y1_y2_y3_y4` =
| outcomes_index | relative_logLR | npc_outcome | |
|---|---|---|---|
| <int> | <dbl> | <dbl> | |
| AC | 3 | 2.2861263 | 0.9896653 |
| DLPFC | 2 | 1.6324724 | 0.9618010 |
| PCC | 4 | 1.1526294 | 0.9002670 |
| Mic | 1 | 0.3500961 | 0.5035101 |
colocboost_plot(res, variant_coord = TRUE, pos = c(25100:26300), plot_cols = 1)
