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Mendelian Randomization (MR)

Source: R/mr.R
mr_analysis.Rd

Mendelian Randomization (MR)

Usage

mr_analysis(mr_formatted_input, cpip_cutoff = 0.5)

Arguments

mr_formatted_input

the output of twas_mr_format_input function

cpip_cutoff

the threshold of cumulative posterior inclusion probability, default is 0.5

Value

A single data frame of output with columns "gene_name", "num_CS", "num_IV", "meta_eff", "se_meta_eff", "meta_pval", "Q", "Q_pval" and "I2". "gene_name" is ensemble ID. "num_CS" is the number of credible sets contained in each gene, "num_IV" is the number of variants contained in each gene. "meta_eff", "se_meta_eff" and "meta_pval" are the MR estimate, standard error and pvalue. "Q" is Cochran’s Q statistic, "I2" quantifies the heterogeneity, range from 0 to 1.