DerSimonian-Laird random-effects meta-analysis of one S-LDSC
quantity for one annotation across multiple traits.
Usage
meta_sldsc_random(
per_trait_estimates,
category,
quantity = c("tau_star", "enrichment", "enrichstat")
)
Arguments
- per_trait_estimates
Named list of per-trait results (each with a
`summary` data frame).
- category
Character. Annotation name to meta-analyze.
- quantity
Character: `"tau_star"`, `"enrichment"`, or `"enrichstat"`.
Value
List with `mean`, `se`, `p`, `n_traits`, `traits_used`, `tau2`.
Details
Per-trait \(SE_i\) sources:
- `quantity = "tau_star"`: jackknife SE from per-block \(\tau^*\).
- `quantity = "enrichment"`: polyfun-reported `Enrichment_std_error`.
- `quantity = "enrichstat"`: back-solved SE from polyfun's `Enrichment_p`.