April 20, 2025: Manuscript describing ColocBoost methods
with applications is posted on medRxiv.
May 2, 2025: colocboost R package is available
on CRAN.
Software updates
v1.0.9 Improvements to summary-statistics workflows,
trait-specific result filtering, and computational efficiency.
Added X_ref support as a memory-efficient alternative
to precomputed LD matrices for large summary-statistics analyses.
Added get_robust_ucos to recalibrate and summarize
robust trait-specific, uncolocalized events.
Improved computational efficiency for repeated matrix products in
large reference-panel workflows.
Improved plotting robustness for extreme association signals and
coefficient or z-score displays.
Minor robustness fixes for summary-statistics analyses with
reference-panel or LD-free inputs.
v1.0.7 Improvements to ColocBoost (check out the full
details in PR and PR).
Enhanced colocboost main function with post-filtering
and only keep the robust colocalization events.
Enhanced colocboost_plot function with flexible
highlighting options and new visualization styles.
Optimized performance and computational efficiency
Improved documentation and examples for the wrapper pipeline
Minor bug fixes for increased stability
v1.0.6 Memory optimization and visualization
improvements with bug fixes CRAN.
Optimized LD-free version to reduce memory usage by eliminating
large identity LD matrix generation
Enhanced colocboost_plot function with improved
horizontal and vertical spacing labels
Resolved minor bugs for improved stability For detailed changelog,
see PR.
v1.0.4 Initial public stable release on CRAN. Due to
the file size limitation of CRAN release, all example data are the
subset of the simulated data. See full dataset in colocboost paper
repo.
v1.0.0 Initial public release. Pre-release versions
0.1.* for reproducing our earlier work, including the first
version of manuscript on medRxiv, are still available on GitHub.