Estimate SNP Heritability — estimateH2 • pecotmr

Estimate SNP heritability from GWAS summary statistics using one of three methods: LDER, g-LDSC, or HDL/sHDL.

Usage

estimateH2(
  sumstats,
  ld_ref,
  method = "lder",
  annotations = NULL,
  local = FALSE,
  ...
)

# S4 method for class 'GWASSumStats,LDStatistic'
estimateH2(
  sumstats,
  ld_ref,
  method = "lder",
  annotations = NULL,
  local = FALSE,
  ...
)

Arguments

sumstats: A GWASSumStats object.
ld_ref: An LDStatistic object (method-appropriate subclass).
method: Character, one of "lder", "gldsc", "hdl".
annotations: An AnnotationMatrix object, or NULL for unstratified estimation.
local: Logical, whether to compute per-block local estimates.
...: Additional method-specific arguments.

Value

An H2Estimate object.