ROSMAP DLPFC Brain Metabolomics QTL#

Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP) brain tissue metabolomics QTL analysis.

Please refer to this document for an overview of the ROSMAP project.

Contact#

FunGen-xQTL Analysis Team

Study Overview#

  • Study name: ROSMAP DLPFC brain metabolomics QTL (metaQTL)
  • Study Description: Metabolite quantitative trait loci (metaQTL) analysis using 600 metabolites measured in DLPFC brain tissue from ROSMAP donors. Metabolomics data were profiled using untargeted mass spectrometry.
  • Tissue: Dorsolateral prefrontal cortex (DLPFC)
  • Metabolites: ~600 metabolites (untargeted mass spectrometry)
  • Cohort: ROSMAP

Analysis Details#

Path(s) to cis-QTL association testing#

  • s3://statfungen/ftp_fgc_xqtl/analysis_result/cis_association/ROSMAP/metaQTL/DLPFC/

Path(s) to fine-mapping with SuSiE RSS model#

Fine-mapping model objects (SuSiE-RSS, .rds) are available in the finemapping models folder (syn69670592).

Path(s) to colocalization#

Multi-context colocalization models (ColocBoost): syn69670597

AD GWAS–xQTL colocalization results: syn69865816

AD GWAS–xQTL colocalization models: syn69670630