FunGen-xQTL Resources

ROSMAP DLPFC Brain Metabolomics QTL

Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP) brain tissue metabolomics QTL analysis.

Please refer to this document for an overview of the ROSMAP project.

Cohort
ROSMAPReligious Orders Study and Rush Memory and Aging Project
Modality
metQTLQTL results
Tissue or cell type
DLPFC
Sample size
Not recorded on this page
Release status
Stagednot yet verified
Access
ControlledData use certificate
Lead analysts
FunGen-xQTL Analysis TeamContact by name
Source data
ROSMAP DLPFC Metabolomics
Open syn69670592 in Synapse ↗ Query associations in the xQTL Atlas ↗

Access

Controlled access. Request data access for ROSMAP on the AD Knowledge Portal; you need a Synapse account. See How to get the data.

WhereIDAccessWhat you get
Synapsesyn69670592ControlledResults described below

Other Synapse IDs on this page syn69670597 syn69865816 syn69670630

shell
pip install synapseclient
synapse login
synapse get -r syn69670592

Contact

FunGen-xQTL Analysis Team

Study Overview

  • Study name: ROSMAP DLPFC brain metabolomics QTL (metQTL)
  • Study Description: Metabolite quantitative trait loci (metQTL) analysis using 600 metabolites measured in DLPFC brain tissue from ROSMAP donors. Metabolomics data were profiled using untargeted mass spectrometry.
  • Tissue: Dorsolateral prefrontal cortex (DLPFC)
  • Metabolites: ~600 metabolites (untargeted mass spectrometry)
  • Cohort: ROSMAP

Analysis Details

Path(s) to fine-mapping with SuSiE RSS model

Fine-mapping model objects (SuSiE-RSS, .rds) are available in the finemapping models folder (syn69670592).

Path(s) to colocalization

Multi-context colocalization models (ColocBoost): syn69670597

AD GWAS–xQTL colocalization results: syn69865816

AD GWAS–xQTL colocalization models: syn69670630