ROSMAP snATAC-seq Chromatin Accessibility#

Summary#

Single-nucleus ATAC-seq (snATAC-seq) data from ROSMAP, profiling chromatin accessibility in individual nuclei from DLPFC brain tissue. Includes data from MIT cohort (single-site) and harmonized CUIMC + MIT Multiome ATAC data.

Dataset Information#

  • Cohort: ROSMAP (MIT single-site; CUIMC + MIT harmonized Multiome)
  • Brain region: Dorsolateral prefrontal cortex (DLPFC)
  • Data type: Single-nucleus ATAC-seq (snATAC-seq)
  • Cell types: Multiple brain cell types (neurons, oligodendrocytes, astrocytes, microglia, etc.)
  • Platform: 10x Genomics Multiome (ATAC+GEX)

Omics Data#

Chromatin accessibility matrices#

Peak-by-cell count matrices and pseudobulk accessibility profiles available through Synapse.

QTL Analysis#

QTL analysis for this dataset is documented in ../../qtl/caQTL/ROSMAP_snuc_caQTL_qtl.md.

Flagship paper analyses: