<?xml version="1.0" encoding="utf-8" standalone="yes"?><rss version="2.0" xmlns:atom="http://www.w3.org/2005/Atom"><channel><title>Histone ChIP-seq Data on FunGen-AD Resources</title><link>https://statfungen.github.io/xqtl-resources/xqtl-data/omics/histone_ChIPSeq/</link><description>Recent content in Histone ChIP-seq Data on FunGen-AD Resources</description><generator>Hugo</generator><language>en-us</language><atom:link href="https://statfungen.github.io/xqtl-resources/xqtl-data/omics/histone_ChIPSeq/index.xml" rel="self" type="application/rss+xml"/><item><title>ROSMAP DLPFC H3K9ac</title><link>https://statfungen.github.io/xqtl-resources/xqtl-data/omics/histone_ChIPSeq/ROSMAP_DLPFC_ChIPSeq_H3K9ac/</link><pubDate>Mon, 01 Jan 0001 00:00:00 +0000</pubDate><guid>https://statfungen.github.io/xqtl-resources/xqtl-data/omics/histone_ChIPSeq/ROSMAP_DLPFC_ChIPSeq_H3K9ac/</guid><description>&lt;h1 id="rosmap-dlpfc-h3k9ac"&gt;ROSMAP DLPFC H3K9ac&lt;a class="anchor" href="#rosmap-dlpfc-h3k9ac"&gt;#&lt;/a&gt;&lt;/h1&gt;
&lt;p&gt;Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP) h3k9ac data-set.&lt;/p&gt;
&lt;p&gt;Please refer to &lt;a href="https://statfungen.github.io/xqtl-resources/xqtl-data/study_info/ROSMAP/"&gt;this document&lt;/a&gt; for an overview of the ROSMAP project.&lt;/p&gt;
&lt;h2 id="contact"&gt;Contact&lt;a class="anchor" href="#contact"&gt;#&lt;/a&gt;&lt;/h2&gt;
&lt;p&gt;Xuanhe Chen; Hao Sun; Hans Klein&lt;/p&gt;
&lt;ul&gt;
&lt;li&gt;Contact Email : &lt;a href="mailto:xuanhechenxhc@163.com"&gt;xuanhechenxhc@163.com&lt;/a&gt;; &lt;a href="mailto:hs3163@cumc.columbia.edu"&gt;hs3163@cumc.columbia.edu&lt;/a&gt;; &lt;a href="mailto:hk2948@cumc.columbia.edu"&gt;hk2948@cumc.columbia.edu&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;Contact Affiliation : Columbia University&lt;/li&gt;
&lt;li&gt;Contact Role : Xuanhe Chen performed QTL analysis using H3K9ac peaks; Hao Sun performed univariate fine-mapping, Hans Klein performed peak calling&lt;/li&gt;
&lt;/ul&gt;
&lt;h2 id="study-overview"&gt;Study Overview&lt;a class="anchor" href="#study-overview"&gt;#&lt;/a&gt;&lt;/h2&gt;
&lt;ul&gt;
&lt;li&gt;Grant number : U01AG046152, R01AG048015, U01AG061356, R01AG15819, U01AG061359&lt;/li&gt;
&lt;li&gt;Publication : PMID: 30084846&lt;/li&gt;
&lt;li&gt;Acknowledgement : Study data were generated from postmortem brain tissue provided by the Religious Orders Study and Rush Memory and Aging Project (ROSMAP) cohort at Rush Alzheimer&amp;rsquo;s Disease Center, Rush University Medical Center, Chicago.&lt;/li&gt;
&lt;li&gt;Study name : ROSMAP DLPFC H3K9ac peak calling&lt;/li&gt;
&lt;li&gt;Study Description : Performed peak calling on 669 ROSMAP samples&amp;rsquo; h3k9ac samples via the ADSP FGC xQTL pipeline. The output format is prepared for haQTL analysis.&lt;/li&gt;
&lt;li&gt;Disease : Alzheimer’s Disease&lt;/li&gt;
&lt;li&gt;Data Citation : Omics data: &lt;a href="https://www.synapse.org/Synapse:syn4896408"&gt;syn4896408&lt;/a&gt;; Genetics data: &lt;a href="https://dss.niagads.org/datasets/ng00067/"&gt;ng00067&lt;/a&gt;&lt;/li&gt;
&lt;li&gt;Additional study information : The phenotype data is an improved version (used advanced method and identified more peaks) of this published ROSMAP hak9ac readcounts: &lt;a href="https://www.synapse.org/#!Synapse:syn17016212"&gt;https://www.synapse.org/#!Synapse:syn17016212&lt;/a&gt;.&lt;/li&gt;
&lt;/ul&gt;
&lt;h2 id="dataset-details"&gt;Dataset Details&lt;a class="anchor" href="#dataset-details"&gt;#&lt;/a&gt;&lt;/h2&gt;
&lt;h3 id="sample-collection-should-be-added-together"&gt;Sample collection （should be added together）&lt;a class="anchor" href="#sample-collection-should-be-added-together"&gt;#&lt;/a&gt;&lt;/h3&gt;
&lt;p&gt;In our haQTL anlaysis, we executed an association study centered on the histone 3 lysine 9 acetylation (H3K9ac) mark, utilizing a cohort of 669 samples from the ROSMAP DLPFC dataset. Subsequent to mapping these samples to Whole Genome Sequencing (WGS) data from the identical dataset, and incorporating an overlap with the ROSMAP joint call, we refined the sample pool to 596 for the ensuing haQTL mapping analysis.&lt;/p&gt;</description></item></channel></rss>