ROSMAP DLPFC Glycoproteomics#

Religious Orders Study (ROS) or the Rush Memory and Aging Project (MAP) DLPFC glycoproteomics (N-glycosylation proteomics).

Please refer to this document for an overview of the ROSMAP project.

Contact#

FunGen-xQTL Analysis Working Group

Study Overview#

  • PI: David A. Bennett (Rush University Medical Center, Chicago, IL, USA)
  • Grant numbers: U01AG046152, R01AG048015, U01AG061356, R01AG15819, U01AG061359
  • Publication: PMID: 30084846
  • Genetics publication: PMID: 40407102
  • Acknowledgement: Study data were generated from postmortem brain tissue provided by the Religious Orders Study and Rush Memory and Aging Project (ROSMAP) cohort at Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago.
  • Omics data: syn17015098
  • Genetics data: ng00067
  • Disease: Alzheimer’s Disease

Dataset Details#

Overview#

Glycoproteomics data profiling N-glycosylation of proteins from dorsolateral prefrontal cortex (DLPFC) tissue of ROSMAP participants. Protein glycosylation is quantified alongside standard protein abundance to characterize post-translational modifications relevant to Alzheimer’s disease pathology.

  • Brain region: Dorsolateral prefrontal cortex (DLPFC)
  • Data type: Glycoproteomics (N-glycosylation mass spectrometry)
  • Platform: Tandem mass tag (TMT) isobaric labeling mass spectrometry

Molecular Phenotype Matrices#

Glycopeptide abundance matrices normalized from TMT-based mass spectrometry data. Available through Synapse at syn17015098.

QTL Analysis#

QTL analysis for this dataset is documented in ../../qtl/gpQTL/ROSMAP_DLPFC_glycoproteomics_qtl.md.

Flagship paper analyses: