FunGen-xQTL computational protocol

Molecular QTL analysis from raw genotypes and phenotypes through discovery, meta-analysis, fine-mapping and GWAS integration.

Tell us about your data and goal

Inputs

Reference Data

Quantification

Molecular Phenotype Quantification

Bulk RNA-seq
Single-nuclei / pseudobulk
Alternative splicing
DNA methylation
Polyadenylation

Pre-processing

Data Pre-processing

Genotype
Phenotype
Covariate

Discovery

QTL Association Testing

Multivariate modelling

Cross-cohort Meta-analysis

Multivariate Mixture (MASH)

Regression

High-dimensional Regression

Individual level
Summary statistics level

Integration

GWAS Integration

Rare-variant xQTL

Interpretation

Enrichment & Validation

xQTL Modifier Score